Angiogenin Defines Heterogeneity at the Core of the Hematopoietic Niche.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 27588743.
- Also identified by DOI 10.1016/j.stem.2016.08.017.
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Abstract
Successful hematopoietic regeneration demands preservation of stemness while enabling expansion and differentiation into blood lineages. Now, Silberstein et al. (2016) and Goncalves et al. (2016) identify a ribonuclease secreted by proximal niche cells that simultaneously drives quiescence of HSCs and proliferation of myeloid progenitors and dramatically enhances hematopoietic recovery after HSC transplantation.
Medical subject headings
- Hematopoietic Stem Cells
- Stem Cell Niche