Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[<sup>18</sup>F]fluoro-D-glucose positron emission and computed tomography.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 27595321.
- Also identified by DOI 10.1038/nm.4161 and PMC identifier 5055809.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-therapy-naive, HIV-1-infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were substantially more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers that are predictive of progression.
Medical subject headings
- HIV Infections
- Latent Tuberculosis
- Tuberculosis, Pulmonary
Anatomy
- thoracic spine