Probing the Diversity of T Cell Dysfunction in Cancer.
editorial · Level V
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- Record sourced from PubMed, PMID 27610560.
- Also identified by DOI 10.1016/j.cell.2016.08.058 and PMC identifier 5523106.
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Abstract
T cell dysfunction in cancer comes in many forms, with two new varieties reported in this issue. Daley et al. find that T cells expressing γδ T cell receptors (TCR) promote pancreatic tumor growth by inhibiting activation of T cells with conventional TCRs. Singer et al. characterize dysfunctional tumor infiltrating lymphocytes to reveal a role for zinc homeostasis in anti-tumor immunity.
Medical subject headings
- Neoplasms
- Receptors, Antigen, T-Cell, gamma-delta