Identification of Gastric Cancer Biomarkers Using 1H Nuclear Magnetic Resonance Spectrometry.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27611679.
- Also identified by DOI 10.1371/journal.pone.0162222 and PMC identifier 5017672.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Existing gastric cancer diagnosing methods were invasive, hence, a reliable non-invasive gastric cancer diagnosing method is needed. As a starting point, we used 1H NMR for identifying gastric cancer biomarkers using a panel of gastric cancer spheroids and normal gastric spheroids. We were able to identify 8 chemical shift biomarkers for gastric cancer spheroids. Our data suggests that the cancerous and non-cancerous spheroids significantly differ in the lipid composition and energy metabolism. These results encourage the translation of these biomarkers into in-vivo gastric cancer detection methodology using MRI-MS.
Medical subject headings
- Biomarkers, Tumor
- Magnetic Resonance Spectroscopy
- Stomach Neoplasms