Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27612591.
- Also identified by DOI 10.1016/j.ebiom.2016.08.033 and PMC identifier 5078574.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Human prion diseases are neurodegenerative disorders caused by abnormally folded prion proteins in the central nervous system. These proteins can be detected using the quaking-induced conversion assay. Compared with other bioassays, this assay is extremely sensitive and was used in the present study to determine prion distribution in sporadic Creutzfeldt-Jakob disease patients at autopsy. Although infectivity of the sporadic form is thought to be restricted within the central nervous system, results showed that prion-seeding activities reach 10<sup>6</sup>/g from a 50% seeding dose in non-neuronal tissues, suggesting that prion-seeding activity exists in non-neural organs, and we suggested that non-neural tissues of 10<sup>6</sup>/g SD50 did not exist the infectivity.
Medical subject headings
- Creutzfeldt-Jakob Syndrome
- Prion Proteins