Multivariable normal tissue complication probability model-based treatment plan optimization for grade 2-4 dysphagia and tube feeding dependence in head and neck radiotherapy.

Abstract

Radiotherapy of the head and neck is challenged by the relatively large number of organs-at-risk close to the tumor. Biologically-oriented objective functions (OF) could optimally distribute the dose among the organs-at-risk. We aimed to explore OFs based on multivariable normal tissue complication probability (NTCP) models for grade 2-4 dysphagia (DYS) and tube feeding dependence (TFD). One hundred head and neck cancer patients were studied. Additional to the clinical plan, two more plans (an OF_DYS and OF_TFD-plan) were optimized per patient. The NTCP models included up to four dose-volume parameters and other non-dosimetric factors. A fully automatic plan optimization framework was used to optimize the OF_NTCP-based plans. All OF_NTCP-based plans were reviewed and classified as clinically acceptable. On average, the Δdose and ΔNTCP were small comparing the OF_DYS-plan, OF_TFD-plan, and clinical plan. For 5% of patients NTCP_TFD reduced >5% using OF_TFD-based planning compared to the OF_DYS-plans. Plan optimization using NTCP_DYS- and NTCP_TFD-based objective functions resulted in clinically acceptable plans. For patients with considerable risk factors of TFD, the OF_TFD steered the optimizer to dose distributions which directly led to slightly lower predicted NTCP_TFD values as compared to the other studied plans.