Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27618651.
- Also identified by DOI 10.1038/nm.4193 and PMC identifier 5365281.
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Abstract
We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic evaluation.
Medical subject headings
- Brain
- Fetus
- Pregnancy Complications, Infectious
- Zika Virus Infection