Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.
Where this comes from
- Record sourced from PubMed, PMID 27622512.
- Also identified by DOI 10.1371/journal.pone.0161157 and PMC identifier 5021350.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling, and bound Notch-fc in a cell-based assay. DNER is not a Notch ligand and its true function remains unknown.
Medical subject headings
- Nerve Tissue Proteins
- Receptors, Cell Surface
- Receptors, Notch