Specialized Hub Beta Cells Trade Maximal Insulin Production for Perfect Timing.
Level V
Where this comes from
- Record sourced from PubMed, PMID 27626196.
- Also identified by DOI 10.1016/j.cmet.2016.08.022.
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Abstract
The pulsatility of insulin release is disturbed early in type 2 diabetes, but it is not clear whether specialized pacemaker cells drive islet oscillations. In this issue of Cell Metabolism, Johnston et al. (2016) show that specialized hubs, identified as 1%-10% of beta cells with more active mitochondria and less insulin, synchronize beta cell oscillations.
Medical subject headings
- Diabetes Mellitus, Type 2
- Insulin