Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27626199.
- Also identified by DOI 10.1016/j.cmet.2016.08.013 and PMC identifier 5024735.
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Abstract
Itaconate is a newly discovered mammalian metabolite bearing significant implications for our understanding of cellular immunometabolism and antimicrobial defense. Here, we explore recent findings regarding the role of itaconate in the innate immune response and highlight the emerging principle that metabolites can have distinct immunological functions independent of bioenergetics.
Medical subject headings
- Anti-Infective Agents
- Food
- Metabolome
- Succinates