Engineered Nanoplatelets for Enhanced Treatment of Multiple Myeloma and Thrombus.

Hu, Quanyin; Qian, Chenggen; Sun, Wujin; Wang, Jinqiang; Chen, Zhaowei; Bomba, Hunter N; Xin, Hongliang; Shen, Qundong et al. · Adv Mater · 2016

basic_science · Level V

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Abstract

A platelet-membrane-coated biomimetic nanocarrier, which can sequentially target the bone microenvironment and myeloma cells to enhance the drug availability at the myeloma site and decrease off-target effects, is developed for inhibiting multiple myeloma growth and simultaneously eradicating thrombus complication.

Medical subject headings