Protein Profiling of Bladder Urothelial Cell Carcinoma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27626805.
- Also identified by DOI 10.1371/journal.pone.0161922 and PMC identifier 5023150.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
This study aimed to detect protein changes that can assist to understand the underlying biology of bladder cancer. The data showed forty five proteins were found to be differentially expressed comparing tumors vs non-tumor tissues, of which EGFR and cdc2p34 were correlated with muscle invasion and histological grade. Ten proteins (ß-catenin, HSP70, autotaxin, Notch4, PSTPIP1, DPYD, ODC, cyclinB1, calretinin and EPO) were able to classify muscle invasive BCa (MIBC) into 2 distinct groups, with group 2 associated with poorer survival. Finally, 3 proteins (P2X7, cdc25B and TFIIH p89) were independent factors for favorable overall survival.
Medical subject headings
- Protein Array Analysis
- Urinary Bladder Neoplasms