Cancer-Cell-Biomimetic Nanoparticles for Targeted Therapy of Homotypic Tumors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27628433.
- Also identified by DOI 10.1002/adma.201602173.
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Abstract
A unique biomimetic drug-delivery system composed of 4T1-breast-cancer-cell membranes and paclitaxel-loaded polymeric nanoparticles (PPNs) (cell-membrane-coated PPNs), demonstrates superior interactions to its source tumor cells and elongated blood circulation, and displays highly cell-specific targeting of the homotypic primary tumor and metastases, with successful inhibition of the growth and lung metastasis of the breast cancer cells.