Small molecule compounds that induce cellular senescence.
basic_science · Level V
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- Record sourced from PubMed, PMID 27628712.
- Also identified by DOI 10.1111/acel.12518 and PMC identifier 6398529.
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Abstract
To date, dozens of stress-induced cellular senescence phenotypes have been reported. These cellular senescence states may differ substantially from each other, as well as from replicative senescence through the presence of specific senescence features. Here, we attempted to catalog virtually all of the cellular senescence-like states that can be induced by low molecular weight compounds. We summarized biological markers, molecular pathways involved in senescence establishment, and specific traits of cellular senescence states induced by more than fifty small molecule compounds.