Long-Circulating Au-TiO<sub>2</sub> Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer.
basic_science · Level V
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- Record sourced from PubMed, PMID 27643533.
- Also identified by DOI 10.1021/acs.nanolett.6b02547.
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Abstract
Although sonodynamic therapy (SDT) has emerged as a potential alternative to conventional photodynamic therapy, the low quantum yield of the sonosensitizer such as TiO<sub>2</sub> nanoparticles (NPs) is still a major concern. Here, we have developed hydrophilized Au-TiO<sub>2</sub> nanocomposites (HAu-TiO<sub>2</sub> NCs) as sonosensitizers for improved SDT. The physicochemical properties of HAu-TiO<sub>2</sub> NCs were thoroughly studied and compared with their counterparts without gold deposition. Upon exposure of HAu-TiO<sub>2</sub> NCs to ultrasound, a large quantity of reactive oxygen species (ROS) were generated, leading to complete suppression of tumor growth after their systemic administration in vivo. Overall, it was evident that the composites of gold with TiO<sub>2</sub> NPs significantly augmented the levels of ROS generation, implying their potential as SDT agents for cancer therapy.