Humoral Human Lung Allograft Rejection by Tissue-Restricted Non-HLA Antibodies.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 27645977.
- Also identified by DOI 10.1016/j.athoracsur.2016.03.042 and PMC identifier 5030466.
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Abstract
A third of lung recipients have preexisting antibodies against nonhuman leukocyte self-antigens (nHAbs) present in the lung tissue. These nHAbs also form de novo in about 70% of patients within 3 years after transplantation. Both preexisting and de novo nHAbs can cause murine lung allograft dysfunction. However, their role in human transplantation remains unclear. We report hyperacute rejection after right lung transplant in a recipient with preexisting nHAbs. The recipient of the left lung from the same donor had an uneventful initial course, but de novo nHAbs developed at 3 weeks, leading to acute humoral rejection. Both patients were successfully treated with antibody-directed therapies.
Medical subject headings
- Autoantibodies
- Graft Rejection
- HLA Antigens
- Immunotherapy
- Lung Transplantation