Immunopathology alters Th17 cell glucocorticoid sensitivity.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27646878.
- Also identified by DOI 10.1111/all.13051 and PMC identifier 5315659.
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Abstract
Th17 cells contribute to several inflammatory conditions and increasing evidence supports that Th17 cells are glucocorticoid resistant. However, Th17 cells in psoriasis and related diseases are glucocorticoid sensitive. We compare glucocorticoid sensitive and resistant immunological diseases and suggest that several aspects in Th17-related diseases alter glucocorticoid sensitivity of Th17 cells. We identify molecular pathways that are implicated in glucocorticoid sensitivity of Th17 cells in the literature, as this information is useful for developing approaches to overcome glucocorticoid-resistant immunopathology.
Medical subject headings
- Anti-Inflammatory Agents
- Drug Tolerance
- Glucocorticoids
- Th17 Cells