Lifting the Differentiation Embargo.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27662083.
- Also identified by DOI 10.1016/j.cell.2016.08.051.
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Abstract
Effective differentiation therapy for acute myeloid leukemia (AML) has been restricted to a small subset of patients with one defined genetic abnormality. Using an unbiased small molecule screen, Sykes et al. now identify a mechanism of de-repression of differentiation in several models of AML driven by distinct genetic drivers.
Medical subject headings
- Leukemia, Myeloid, Acute
- Lifting