Oriented collagen fibers direct tumor cell intravasation.
basic_science · Level V
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- Record sourced from PubMed, PMID 27663743.
- Also identified by PMC identifier 5056065.
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Abstract
In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).
Medical subject headings
- Collagen
- Neoplasm Metastasis
- Neoplasms