Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27677580.
- Also identified by DOI 10.1038/ncomms12792 and PMC identifier 5052699.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Acute otitis media (AOM) is among the most common pediatric diseases, and the most frequent reason for antibiotic treatment in children. Risk of AOM is dependent on environmental and host factors, as well as a significant genetic component. We identify genome-wide significance at a locus on 6q25.3 (rs2932989, P<sub>meta</sub>=2.15 × 10<sup>-09</sup>), and show that the associated variants are correlated with the methylation status of the FNDC1 gene (cg05678571, P=1.43 × 10<sup>-06</sup>), and further show it is an eQTL for FNDC1 (P=9.3 × 10<sup>-05</sup>). The mouse homologue, Fndc1, is expressed in middle ear tissue and its expression is upregulated upon lipopolysaccharide treatment. In this first GWAS of AOM and the largest OM genetic study to date, we identify the first genome-wide significant locus associated with AOM.