In Situ Observation of Single-Molecule Surface Reactions from Low to High Affinities.
basic_science · Level V
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- Record sourced from PubMed, PMID 27677787.
- Also identified by DOI 10.1002/adma.201603153.
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Abstract
In situ observation of single-molecule surface reactions from low to high affinities is achieved by resonant coupling between optical whispering-gallery modes and the localized surface plasmon of nanorods. Transient and permanent interactions between ligands (thiol, amine) and the gold surface are monitored without labels, allowing direct determination of the associated kinetic constants and rapid development of new functionalization protocols.