Home Environment as a Source of Life-Threatening Azole-Resistant Aspergillus fumigatus in Immunocompromised Patients.
case_report · Level V
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- Record sourced from PubMed, PMID 27682064.
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Abstract
A case of fatal aspergillosis due to a TR<sub>46</sub>/Y121F/T289A azole-resistant Aspergillus fumigatus is reported. Environmental investigations at the patient's residence led to the recovery of TR<sub>46</sub>/Y121F/T289A isolates, genotypically indistinguishable from the clinical isolate, supporting for the first time the direct role of household as potential source of azole-resistant invasive aspergillosis.
Medical subject headings
- Antifungal Agents
- Aspergillosis
- Aspergillus fumigatus
- Azoles
- Drug Resistance, Fungal
- Immunocompromised Host