EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27697766.
- Also identified by DOI 10.1158/0008-5472.CAN-16-0842.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The lack of effective tumor-associated antigens restricts the development of targeted therapies against myeloid leukemia. In this study, we compared gene expression patterns of acute myeloid leukemia (AML) and normal bone marrow samples and found that epithelial cell adhesion molecule (EpCAM) is frequently overexpressed in patients with AML, with EpCAM<sup>+</sup> leukemic cells exhibiting enhanced chemoresistance and oncogenesis. The chemotherapeutic resistance of EpCAM-positive leukemic cells is a consequence of increased WNT5B signaling. Furthermore, we generated EpCAM antibodies that enabled phagocytosis or cytotoxicity of AML cells by macrophage or natural killer cells, respectively. Finally, EpCAM antibody treatment depleted AML in subcutaneous, disseminated, and intramedullary engrafted mice. In summary, EpCAM exhibits promise as a novel target for the treatment of leukemia. Cancer Res; 77(2); 482-93. ©2016 AACR.
Medical subject headings
- Drug Resistance, Neoplasm
- Epithelial Cell Adhesion Molecule
- Immunologic Surveillance
- Leukemia, Myeloid, Acute