Divergent effects of central melanocortin signalling on fat and sucrose preference in humans.
Where this comes from
- Record sourced from PubMed, PMID 27701398.
- Also identified by DOI 10.1038/ncomms13055 and PMC identifier 5059464.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Melanocortin-4-receptor (MC4R)-expressing neurons modulate food intake and preference in rodents but their role in human food preference is unknown. Here we show that compared with lean and weight-matched controls, MC4R deficient individuals exhibited a markedly increased preference for high fat, but a significantly reduced preference for high sucrose food. These effects mirror those in Mc4r null rodents and provide evidence for a central molecular circuit influencing human macronutrient preference.
Medical subject headings
- Dietary Fats
- Dietary Sugars
- Feeding Behavior
- Receptor, Melanocortin, Type 4
- Sucrose