CD4+ T Cells Coexpressing CD134 (OX40) Harbor Significantly Increased Levels of Human Herpesvirus 6B DNA Following Umbilical Cord Blood Transplantation.
case_series · Level IV
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- Record sourced from PubMed, PMID 27703035.
- Also identified by PMC identifier 5142091.
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Abstract
Human herpesvirus 6B (HHV-6B) commonly reactivates after umbilical cord blood transplantation (UCBT) and is associated with delayed engraftment, fever, rash, and central nervous system dysfunction. Recently, CD134 (OX40) has been implicated as a potential viral entry receptor. We evaluated CD4<sup>+</sup>CD134<sup>+</sup>/<sup>neg-lo</sup> and CD8<sup>+</sup>CD134<sup>+</sup>/<sup>neg-lo</sup> cells at day 28 after UCBT in 20 subjects with previously documented HHV-6 reactivation and persistent viremia. Analysis of CD4<sup>+</sup>CD134<sup>+</sup> cells as compared to CD4<sup>+</sup>CD134<sup>neg-lo</sup> cells showed 0.308 versus 0.129 copies of HHV-6B/cell (P = .0002). CD8<sup>+</sup>CD134<sup>+/neg-lo</sup> cells contained little to no HHV-6B copies. Following UCBT, CD4<sup>+</sup>CD134<sup>+</sup> cells harbor significantly increased levels of HHV-6B, suggesting that CD134 (OX40) may facilitate viral entry.
Medical subject headings
- CD4-Positive T-Lymphocytes
- DNA, Viral
- Fetal Blood
- Herpesvirus 6, Human
- Receptors, OX40
- Roseolovirus Infections
- Transplantation