Regulating Stem Cell Secretome Using Injectable Hydrogels with In Situ Network Formation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27709809.
- Also identified by DOI 10.1002/adhm.201600497 and PMC identifier 5521188.
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Abstract
A family of shear-thinning hydrogels for injectable encapsulation and long-term delivery (SHIELD) has been designed and synthesized with controlled in situ stiffening properties to regulate the stem cell secretome. The authors demonstrate that SHIELD with an intermediate stiffness (200-400 Pa) could significantly promote the angiogenic potential of human adipose-derived stem cells.
Medical subject headings
- Adipose Tissue
- Hydrogels
- Stem Cells