Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27713410.
- Also identified by DOI 10.1038/ncomms13052 and PMC identifier 5059759.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
DNA N<sup>6</sup>-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to ∼0.1-0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the progression of the embryo development. During this process a large fraction of 6mAs locate in repetitive regions of the genome.
Medical subject headings
- DNA
- DNA Methylation
- Deoxyadenosines
- Embryonic Development
- Swine
- Zebrafish