Empowering Older Antibiotics.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27716499.
- Also identified by DOI 10.1016/j.cell.2016.09.032.
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Abstract
Avycaz combines an older cephalosporin antibiotic, ceftazidime, and the β-lactamase inhibitor avibactam. Ceftazidime targets penicillin-binding proteins (PBPs) in the bacterial periplasm that are required for cell wall synthesis. Avibactam blocks β-lactamases (β-L) in the periplasm, which would otherwise inactivate the antibiotics resulting in drug resistance.
Medical subject headings
- Anti-Bacterial Agents
- Azabicyclo Compounds
- Bacteria
- Ceftazidime
- Penicillin-Binding Proteins
- beta-Lactamase Inhibitors