Remembering the Past: A New Form of Protein-Based Inheritance.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27716500.
- Also identified by DOI 10.1016/j.cell.2016.09.036.
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Abstract
A comprehensive analysis uncovered a set of yeast proteins promoting protein-based inheritance that shares many of the non-Mendelian properties of prions. Lacking any sequence or structural signatures of known prions, these proteins represent a new class of non-amyloid, protein-based epigenetic determinants that can control phenotype without impacting genotype.
Medical subject headings
- Epigenesis, Genetic
- HSP70 Heat-Shock Proteins
- HSP90 Heat-Shock Proteins
- Heat-Shock Proteins
- Heredity
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins