Coordination of Two Genomes by Mitochondrial Translational Plasticity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27716503.
- Also identified by DOI 10.1016/j.cell.2016.09.042.
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Abstract
The dual genetic origin of mitochondrial respiratory chain complexes leads to the synthesis of subunits by mitochondrial and cytosolic ribosomes. Now, Richter-Dennerlein et al. report that membrane-integrated assembly factors associate with ribosome nascent chain complexes in human mitochondria to coordinate translational plasticity with the import of subunits from the cytosol.
Medical subject headings
- Protein Biosynthesis
- Ribosomes