PIWI Takes a Giant Step.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27716504.
- Also identified by DOI 10.1016/j.cell.2016.09.043.
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Abstract
piRNA guides the action of PIWI proteins to silence deleterious transposons in animal reproductive tissues. Biogenesis of piRNA-induced silencing complex (piRISC) involves a multi-step process. In this issue, Matsumoto et al. report the first crystal structure of a PIWI-clade protein displaying a guide RNA, ready for action.
Medical subject headings
- Argonaute Proteins
- Drosophila Proteins