Mucus-Penetrating Nanosuspensions for Enhanced Delivery of Poorly Soluble Drugs to Mucosal Surfaces.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27717163.
- Also identified by DOI 10.1002/adhm.201600599 and PMC identifier 5586074.
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Abstract
Mucus-penetrating nanosuspensions, consisting of pure hydrophobic therapeutics with dense muco-inert coatings that enable particles to effectively bypass the mucus barrier, demonstrate superior drug distribution and absorption at mucosal surfaces. With significantly increased drug load compared to polymeric systems and established clinical translation of nanosuspensions-based products, mucus-penetrating nanosuspensions are a promising vehicle for improving mucosal delivery of poorly soluble drugs.
Medical subject headings
- Mucus
- Nanoparticles
- Pharmaceutical Preparations
- Suspensions