Local Delivery of PHD2 siRNA from ROS-Degradable Scaffolds to Promote Diabetic Wound Healing.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27717176.
- Also identified by DOI 10.1002/adhm.201600820 and PMC identifier 5152672.
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Abstract
Small interfering RNA (siRNA) delivered from reactive oxygen species-degradable tissue engineering scaffolds promotes diabetic wound healing in rats. Porous poly(thioketal-urethane) scaffolds implanted in diabetic wounds locally deliver siRNA that inhibits the expression of prolyl hydroxylase domain protein 2, thereby increasing the expression of progrowth genes and increasing vasculature, proliferating cells, and tissue development in diabetic wounds.
Medical subject headings
- Diabetes Mellitus
- Procollagen-Proline Dioxygenase
- RNA, Small Interfering
- Reactive Oxygen Species
- Wound Healing