Copolymer-Mediated Cell Aggregation Promotes a Proangiogenic Stem Cell Phenotype In Vitro and In Vivo.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27717208.
- Also identified by DOI 10.1002/adhm.201600819 and PMC identifier 5152909.
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Abstract
Material-induced cell aggregation drives a proangiogenic expression profile. Copolymer substrates containing cell-repellent and cell-adhesive domains force the aggregation of human mesenchymal stem cells, which results in enhanced tubulogenesis in vitro and stabilization of vasculature in vivo. These findings can be used to design instructive biomaterial scaffolds for clinical use.
Medical subject headings
- Biocompatible Materials
- Cell Aggregation
- Mesenchymal Stem Cells
- Polymers