Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27721447.
- Also identified by DOI 10.1038/ncomms13116 and PMC identifier 5062562.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Invariant natural killer T (iNKT) cells comprise a subpopulation of innate lymphocytes developing in thymus. A new model proposes subdividing murine iNKT cells into iNKT1, 2 and 17 cells. Here, we use transcriptome analyses of iNKT1, 2 and 17 subsets isolated from BALB/c and C57BL/6 thymi to identify candidate genes that may affect iNKT cell development, migration or function. We show that Fcɛr1γ is involved in generation of iNKT1 cells and that SerpinB1 modulates frequency of iNKT17 cells. Moreover, a considerable proportion of iNKT17 cells express IL-4 and IL-17 simultaneously. The results presented not only validate the usefulness of the iNKT1/2/17-concept but also provide new insights into iNKT cell biology.
Medical subject headings
- Gene Expression Profiling
- Gene Expression Regulation
- Natural Killer T-Cells
- T-Lymphocyte Subsets