Association and interaction analysis of diabetes mellitus and <i>SCN10A</i> for cardiovascular autonomic neuropathy in a Chinese population.

Abstract

This study assessed the extent to which diabetes mellitus (DM) and <i>SCN10A</i> (rs7375036) and their interaction impact on cardiovascular autonomic neuropathy (CAN) susceptibility in a Chinese Han sample. We performed a study in a cross-sectional dataset that included 419 patients with DM and 1557 controls who were genotyped for the presence of the <i>SCN10A</i> rs7375036 polymorphisms. Genotyping was performed by iPLEX technology. The associations of rs7375036 and DM with CAN was assessed by using univariate and multivariate logistic regression controlling for confounders. The interaction between rs7375036 and DM for CAN susceptibility on an additive scale was calculated by using the relative excess risk due to interaction (RERI), the proportion attributable to interaction (AP), and the synergy index (S). The univariate logistic analyses failed to show an association between the <i>SCN10A</i> rs7375036 polymorphisms and CAN. Interestingly, a novel interaction effect of <i>SCN10A</i> rs7375036 and DM on CAN was assessed (p=0.055; RERI=3.515, 95% CI 1.829 to 5.805; AP=0.632, 95% CI -0.368 to 1.632; S=4.361, 95% CI 2.071 to 9.184). Our findings suggest that there are interaction effects of DM and <i>SCN10A</i> (rs7375036) that influence the development of CAN. NCT02461342.