Overcoming ATM Deficiency by Activating the NAD<sup>+</sup>/SIRT1 Axis.
Level V
Where this comes from
- Record sourced from PubMed, PMID 27732834.
- Also identified by DOI 10.1016/j.cmet.2016.09.019.
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Abstract
In this issue, Fang et al. (2016) show that both the DNA repair defect and mitochondrial dysfunction in ATM-/- cells or mice are mitigated by the anti-aging compound nicotinamide riboside or a SIRT1 activator. This broad suppression by activating the NAD+/SIRT1 axis may generally apply to diseases and aging maladies.
Medical subject headings
- NAD
- Sirtuin 1