Oncometabolite Accumulation and Epithelial-to-Mesenchymal Transition: The Turn of Fumarate.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 27732835.
- Also identified by DOI 10.1016/j.cmet.2016.09.020.
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Abstract
Mutations to the Krebs cycle enzyme fumarate hydratase in cancer cells leads to an accumulation of the oncometabolite fumarate. Sciacovelli et al. (2016) demonstrate an epigenetically dependent epithelial-to-mesenchymal transition mediated by modulation of the miR-200 cluster and TET demethylation in response to fumarate accumulation.
Medical subject headings
- Epithelial-Mesenchymal Transition
- MicroRNAs