Calcium signalling and ER stress in insulin resistance and atherosclerosis.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27739133.
- Also identified by DOI 10.1111/joim.12562 and PMC identifier 5083967.
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Abstract
The burden of type 2 diabetes and its major complication cardiovascular disease is rapidly increasing worldwide. Understanding the underlying pathogenic mechanisms of these diseases is crucial to develop novel therapeutics. Recent work using genetic and biochemical methods in mouse models and human samples have identified disturbed calcium signalling and endoplasmic reticulum stress as emerging factors involved in the pathogenesis of many metabolic diseases. In this review, we will highlight the specific roles of calcium signalling and endoplasmic reticulum stress response in the development of insulin resistance and atherosclerosis.
Medical subject headings
- Atherosclerosis
- Calcium Signaling
- Diabetes Mellitus, Type 2
- Diabetic Angiopathies
- Endoplasmic Reticulum
- Insulin Resistance