Fibroblast growth factor 23: fueling the fire.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 27742194.
- Also identified by DOI 10.1016/j.kint.2016.08.013 and PMC identifier 5914485.
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Abstract
In chronic kidney disease, systemic inflammation is common and associated with mortality. The present study demonstrates that fibroblast growth factor 23 (FGF23) contributes to uremic inflammation by increasing hepatic expression and secretion of inflammatory cytokines. FGF23 binds to hepatic FGFR4, inducing calcineurin/nuclear factor of activated T-cell signaling, resulting in increased expression of interleukin 6 and C-reactive protein. The proinflammatory effects of FGF23 are inhibited by an isoform-specific FGFR4 blocking antibody and by cyclosporine, a calcineurin inhibitor.
Medical subject headings
- Fibroblast Growth Factors
- Renal Insufficiency, Chronic