Mitochondrial dysfunction in obesity-related kidney disease: a novel therapeutic target.
Level V
Where this comes from
- Record sourced from PubMed, PMID 27742195.
- Also identified by DOI 10.1016/j.kint.2016.07.045.
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Abstract
Lipid accumulation in renal cells has been implicated in the pathogenesis of obesity-related kidney disease, but the underlying mechanism is poorly understood. Szeto et al. now unravel a central role of mitochondrial dysfunction in a high fat diet-induced glomerulopathy and proximal tubular injury. Moreover, they demonstrate the renoprotective effect of SS31, a mitochondria-targeted antioxidant, in related models. Targeting mitochondria may offer a novel strategy for the therapy of obesity-related kidney disease.
Medical subject headings
- Diet, High-Fat
- Kidney Diseases