Fabrication of RNA 3D Nanoprisms for Loading and Protection of Small RNAs and Model Drugs.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27758001.
- Also identified by DOI 10.1002/adma.201603180 and PMC identifier 5224701.
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Abstract
Constructing containers with defined shape and size to load and protect therapeutics and subsequently control their release in the human body has long been a dream. The fabrication of 3D RNA prisms, characterized by atomic force microscopy, cryo-electron microscopy, dynamic light scattering, and polyacrylamide gel electrophoresis, is reported for the loading and protection of small molecules, proteins, small RNA molecules, and their controlled release.
Medical subject headings
- Drug Delivery Systems
- Nanostructures
- Nanotechnology
- Pharmaceutical Preparations
- RNA