Neuroinflammatory and morphological changes in late-life depression: the NIMROD study.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 27758838.
- Also identified by PMC identifier 5152879.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We studied neuroinflammation in individuals with late-life depression, as a risk factor for dementia, using [<sup>11</sup>C]PK11195 positron emission tomography (PET). Five older participants with major depression and 13 controls underwent PET and multimodal 3T magnetic resonance imaging (MRI), with blood taken to measure C-reactive protein (CRP). We found significantly higher CRP levels in those with late-life depression and raised [<sup>11</sup>C]PK11195 binding compared with controls in brain regions associated with depression, including subgenual anterior cingulate cortex, and significant hippocampal subfield atrophy in cornu ammonis 1 and subiculum. Our findings suggest neuroinflammation requires further investigation in late-life depression, both as a possible aetiological factor and a potential therapeutic target.
Medical subject headings
- C-Reactive Protein
- Cerebral Cortex
- Major Depressive Disorder
- Inflammation
- Receptors, GABA