Carbon nanotube electrodes for retinal implants: A study of structural and functional integration over time.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27760395.
- Also identified by DOI 10.1016/j.biomaterials.2016.10.018 and PMC identifier 5123641.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The choice of electrode material is of paramount importance in neural prosthetic devices. Electrodes must be biocompatible yet able to sustain repetitive current injections in a highly corrosive environment. We explored the suitability of carbon nanotube (CNT) electrodes to stimulate retinal ganglion cells (RGCs) in a mouse model of outer retinal degeneration. We investigated morphological changes at the bio-hybrid interface and changes in RGC responses to electrical stimulation following prolonged in vitro coupling to CNT electrodes. We observed gradual remodelling of the inner retina to incorporate CNT assemblies. Electrophysiological recordings demonstrate a progressive increase in coupling between RGCs and the CNT electrodes over three days, characterized by a gradual decrease in stimulation thresholds and increase in cellular recruitment. These results provide novel evidence for time-dependent formation of viable bio-hybrids between CNTs and the retina, demonstrating that CNTs are a promising material for inclusion in retinal prosthetic devices.
Medical subject headings
- Electric Stimulation Therapy
- Electrodes, Implanted
- Microelectrodes
- Nanotubes, Carbon
- Retinal Degeneration
- Visual Prosthesis