Biological Activity of Coumarin Derivatives as Anti-Leishmanial Agents.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27768694.
- Also identified by DOI 10.1371/journal.pone.0164585 and PMC identifier 5074534.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Cutaneous leishmaniasis affects nearly 0.7 to 1.3 million people annually. Treatment of this disease is difficult due to lack of appropriate medication and the growing problem of drug resistance. Natural compounds such as coumarins serve as complementary therapeutic agents in addition to the current treatment modalities. In this study, we have performed an in-silico screening of the coumarin derivatives and their anti-leishmanial properties has been explored both in-vitro and in-vivo. One of the compounds (compound 2) exhibited leishmanicidal activity and to further study its properties, nanoliposomal formulation of the compound was developed. Treatment of cutaneous lesions in BALB/c mice with compound 2 showed significantly reduced lesion size as compared to the untreated mice (p<0.05) suggesting that compound 2 may possess anti-leishmanial properties.
Medical subject headings
- Antiprotozoal Agents
- Coumarins
- Leishmaniasis, Cutaneous