A New SV2A Ligand for Epilepsy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27768878.
- Also identified by DOI 10.1016/j.cell.2016.09.057.
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Abstract
Since the 1970s, racetams have been in use as cognitive enhancers. Levetiracetam was discovered to have antiseizure activity in animal models and was then found to bind to SV2A in synaptic and endocrine vesicles. Brivaracetam, an analog of levetiracetam, was identified in a medicinal chemistry campaign with the objective of discovering analogs with higher affinity at racetam-binding sites and greater antiseizure potency.
Medical subject headings
- Anticonvulsants
- Epilepsies, Partial
- Epilepsy, Generalized
- Membrane Glycoproteins
- Nerve Tissue Proteins
- Pyrrolidinones