p62 in Cancer: Signaling Adaptor Beyond Autophagy.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27768885.
- Also identified by DOI 10.1016/j.cell.2016.09.030 and PMC identifier 5114003.
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Abstract
Adaptor proteins participate in selective autophagy, which is critical for cellular detoxification and stress relief. However, new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma.
Medical subject headings
- Autophagy
- Carcinogenesis
- Neoplasms
- Sequestosome-1 Protein
- Tumor Microenvironment