Synergistic thermoradiotherapy based on PEGylated Cu<sub>3</sub>BiS<sub>3</sub> ternary semiconductor nanorods with strong absorption in the second near-infrared window.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27768971.
- Also identified by DOI 10.1016/j.biomaterials.2016.10.024.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In this work, we report a successful synthesis of copper bismuth sulfide nanorods (NRs) with broad and strong photoabsorption ranging from ultraviolet (UV) to near-infrared (NIR) wavelengths, which can be used as a 1064 nm-laser-driven photothermal agent with the photothermal conversion efficiency of 40.7%, noticeably higher than most of the reported PTT agents working in NIR-II window. The as-prepared PEGylated Cu<sub>3</sub>BiS<sub>3</sub> NRs were used as photoacoustic imaging (PAI) and CT imaging agents due to their strong NIR absorption and large X-ray attenuation coefficient of bismuth. We are the first to demonstrate that a small quantity of PEGylated Cu<sub>3</sub>BiS<sub>3</sub> NRs in tumors can concentrate radiation energy and trigger mild PTT under NIR-II irradiation and thus, these particles could be used as a novel, synergistic thermoradiotheraputic agent that enhances the efficacy of radiotherapy.
Medical subject headings
- Combined Modality Therapy
- Hyperthermia, Induced
- Metal Nanoparticles
- Nanotubes
- Neoplasms, Experimental
- Photochemotherapy
- Polyethylene Glycols