Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27773809.
- Also identified by DOI 10.1053/j.gastro.2016.10.015 and PMC identifier 5550896.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Transforming growth factor (TGF)-β cytokines signal via a complex network of pathways to regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. A high percentage of colorectal tumors contain mutations that disrupt TGF-β family member signaling. We review how TGF-β family member signaling is altered during development of colorectal cancer, models of study, interaction of pathways, and potential therapeutic strategies.
Medical subject headings
- Colorectal Neoplasms
- Receptors, Transforming Growth Factor beta
- Signal Transduction
- Smad Proteins
- Transforming Growth Factor beta