Esterase-Activated Charge-Reversal Polymer for Fibroblast-Exempt Cancer Gene Therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27786373.
- Also identified by DOI 10.1002/adma.201603095.
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Abstract
Selective gene expression in tumors via responsive dissociation of polyplexes triggered by intracellular signals is demonstrated. An esterase-responsive charge-reversal polymer mediates selective gene expression in the cancer cells high in esterases over fibroblasts low in esterase activity. Its gene therapy with the TRAIL suicide gene effectively induces apoptosis of HeLa cells but does not activate fibroblasts to secrete WNT16B, enabling potent cancer gene therapy with few side effects.
Medical subject headings
- Esterases
- Fibroblasts
- Gene Expression Regulation, Neoplastic
- Genetic Therapy
- Neoplasms
- Polymers